When released hyperinsulinism excess amount of insulin which reduces blood sugar level and causes a feeling of hunger, which leads to overeating. In addition, insulin inhibits lipolysis and makes inefficient diet. Obesity in this disease tends to progression.
When a tumor of the adrenal or pituitary develops hypercortisolism, which leads to hormonal imbalance. Patients with this type of obesity have a fat body and thin limbs. This disease can develop as a result of long-term treatment with corticosteroids, such as asthma or rheumatoid arthritis.
An important factor in the progression of obesity is low testosterone levels in men and high prolactin levels in women. This slows down the metabolism and stimulates the passage of carbohydrates into fat.
Syndrome of hyperandrogenism in women is also often accompanied by obesity. To this may cause adrenal or ovarian tumors, the lack of certain enzymes or dysregulation of the nervous system after an intoxication. This syndrome also brings cosmetic troubles - excessive body hair on the legs and loss of hair on the head.
Cushing's disease is rarely the cause of obesity. When her fat is stored mostly on the trunk, face becomes lunoobraznym on the neck appear fat pad.
Obesity can also cause injuries of the skull base, the effects of surgery, inflammatory diseases of the brain. It can develop on the background of some mental disease or neuroleptics.
Such genetic defects as increased activity of enzymes of lipogenesis and lipolysis decreased enzyme activity also leads to excess weight.
In the treatment of secondary obesity is the main treatment of the underlying disease.